Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

A variety of mechanosensory neurons are involved in touch, proprioception, and pain. Many
molecular components of the mechanotransduction machinery subserving these sensory …

With sweeping advances in precision delivery systems and manipulation of the genomes
and transcriptomes of various cell types, medical biotechnology offers unprecedented …

Piezo2 transmembrane excitatory mechanosensitive ion channels were identified as the
principal mechanotransduction channels for proprioception. Recently, it was postulated that …

Background Dry eye disease (DED) is a multifactorial disease of the ocular surface
accompanied by neurosensory abnormalities. Here, we evaluated the effectiveness of …

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative multisystem disease, with
an unknown pathomechanism, resulting in progressive motoneuron loss. In 90–95% of …

The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces
colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor …