Sex and gender dimorphisms are found in a large variety of diseases, including sepsis and
septic shock which are more prevalent in men than in women. Animal models show that the …

Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …

The limited reserves of neutrophils are implicated in the susceptibility to infection in
neonates, however the regulation of neutrophil kinetics in infections in early life remains …

Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an
imbalanced immune response to infection. Although an increased inflammatory response …

On the 26 th January 2023, a free to attend,'improving in vivo snake venom research: a
community discussion'meeting was held virtually. This webinar brought together researchers …

Background Calcitonin gene-related peptide (CGRP) and procalcitonin, which are
overexpressed in sepsis, exert distinct immunomodulatory effects mediated through the …

Introduction Clinicians need reliable outcome predictors to improve the prognosis of septic
patients. Mouse models are widely used in sepsis research. We aimed to review how mouse …

We hypothesized that the composition of sepsis-inducing bacterial flora influences the
course of fecal peritonitis in rodents. Saline or fecal suspensions with a standardized dose …

Researchers around the world have rapidly mobilised to work on coronavirus disease 2019
(COVID-19) research. In April, we contributed to a review of early studies using animal …

Sepsis is a syndrome that includes physiological, pathological, and biochemical
abnormalities resulting from the host immune response to infection. Despite the improved …