Regulatory mechanisms of microRNA expression

LF Gulyaeva, NE Kushlinskiy - Journal of translational medicine, 2016 - Springer
MicroRNAs (miRs, miRNAs) are small molecules of 18–22 nucleotides that serve as
important regulators of gene expression at the post-transcriptional level. One of the …

miRNA clusters with down-regulated expression in human colorectal cancer and their regulation

P Pidíkova, R Reis, I Herichova - International journal of molecular …, 2020 - mdpi.com
Regulation of microRNA (miRNA) expression has been extensively studied with respect to
colorectal cancer (CRC), since CRC is one of the leading causes of cancer mortality …

Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders

AH Mahnke, GD Sideridis, NA Salem, AM Tseng… - Scientific Reports, 2021 - nature.com
Prenatal alcohol exposure (PAE) can result in cognitive and behavioral disabilities and
growth deficits. Because alcohol-related neurobehavioral deficits may occur in the absence …

Post‐transcriptional regulation of polycistronic microRNAs

M Vilimova, S Pfeffer - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
An important proportion of microRNA (miRNA) genes tend to lie close to each other within
animal genomes. Such genomic organization is generally referred to as miRNA clusters …

A comprehensive overview of bull sperm-borne small non-coding RNAs and their diversity across breeds

E Sellem, S Marthey, A Rau, L Jouneau, A Bonnet… - Epigenetics & …, 2020 - Springer
Background Mature sperm carry thousands of RNAs, including mRNAs, lncRNAs, tRNAs,
rRNAs and sncRNAs, though their functional significance is still a matter of debate. Growing …

Machine learning-based state-of-the-art methods for the classification of rna-seq data

A Jabeen, N Ahmad, K Raza - … in BioApps: Automation of Decision Making, 2018 - Springer
Ribonucleic acid sequencing (RNA-Seq) measures the expression levels of several
transcripts simultaneously. The readings can be gene, exon, or other regions of interest …

MicroRNAs in brain development and cerebrovascular pathophysiology

Q Ma, L Zhang, WJ Pearce - American Journal of …, 2019 - journals.physiology.org
MicroRNAs (miRNAs) are a class of highly conserved non-coding RNAs with 21–25
nucleotides in length and play an important role in regulating gene expression at the …

Modulation of microRNA-mRNA target pairs by human papillomavirus 16 oncoproteins

ME Harden, N Prasad, A Griffiths, K Munger - MBio, 2017 - Am Soc Microbiol
The E6 and E7 proteins are the major oncogenic drivers encoded by high-risk human
papillomaviruses (HPVs). While many aspects of the transforming activities of these proteins …

Hyperandrogenism and metabolic syndrome are associated with changes in serum-derived microRNAs in women with polycystic ovary syndrome

AE Sørensen, PB Udesen, G Maciag, J Geiger… - Frontiers in …, 2019 - frontiersin.org
Polycystic ovary syndrome (PCOS) remains one of the most common endocrine disorder in
premenopausal women with an unfavorable metabolic risk profile. Here, we investigate …

miRNA–miRNA crosstalk: from genomics to phenomics

J Xu, T Shao, N Ding, Y Li, X Li - Briefings in bioinformatics, 2017 - academic.oup.com
The discovery of microRNA (miRNA)–miRNA crosstalk has greatly improved our
understanding of complex gene regulatory networks in normal and disease-specific …