Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

▪ Abstract Breathing is a vital behavior that is particularly amenable to experimental
investigation. We review recent progress on three problems of broad interest.(i) Where and …

We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Intermittent hypoxia causes a form of serotonin-dependent synaptic plasticity in the spinal
cord known as phrenic long-term facilitation (pLTF). Here we show that increased synthesis …

Although recent evidence demonstrates considerable neuroplasticity in the respiratory
control system, a comprehensive conceptual framework is lacking. Our goals in this review …

Serotonergic neurons project widely throughout the CNS and modulate many different brain
functions. Particularly important, but controversial, are the contributions of serotonin (5-HT) …

Spinal injury disrupts connections between the brain and spinal cord, causing life-long
paralysis. Most spinal injuries are incomplete, leaving spared neural pathways to motor …

Background. Neural plasticity may contribute to motor recovery following spinal cord injury
(SCI). In rat models of SCI with respiratory impairment, acute intermittent hypoxia (AIH) …

Ventilatory responses to hypoxia vary widely depending on the pattern and length of hypoxic
exposure. Acute, prolonged, or intermittent hypoxic episodes can increase or decrease …

Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …