This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

Cancer is the second leading cause of death in humans. Despite rapid developments in
diagnostic methods and therapies, metastasis and resistance to administrated drugs are the …

Nowadays, lung cancer is the most common cause of cancer-related deaths in both men
and women globally. Despite the development of extremely efficient targeted agents, lung …

One of the central regulators of cell growth, proliferation, and metabolism is the mammalian
target of rapamycin, mTOR, which exists in two structurally and functionally different …

Uveal melanoma is the most common primary ocular neoplasm in adults, with many patients
ending up developing liver metastasis and facing a significant reduction of their life …

Invertebrates rely on innate immunity, including humoral and cellular immunity, to resist
pathogenic infection. Previous studies showed that forkhead box transcription factor O …

Simple Summary In the present review, we discuss the role of metabolic reprogramming
which occurs in malignant cells. The process of metabolic reprogramming is also known as …

Simple Summary Several current therapies fail to eradicate tumors due to the ability of
cancer stem cells (CSCs) to escape different programmed cell deaths. In fact, apoptosis …

Nuclear located hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) remains
the key obstacle to cure chronic hepatitis B (CHB). In our previous investigation, it was found …