Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …

The best characterized signaling pathway downstream of transforming growth factor β (TGF-
β) is through SMAD2 and SMAD3. However, TGF-β also induces phosphorylation of SMAD1 …

Light has become established as a tool not only to visualize and investigate but also to steer
biological systems. This review starts by discussing the unique features that make light such …

TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

The development of multicellular organisms is controlled by highly dynamic molecular and
cellular processes organized in spatially restricted patterns. Recent advances in …

During animal development, embryos undergo complex morphological changes over time.
Differences in developmental tempo between species are emerging as principal drivers of …

Cells sense, process, and respond to extracellular information using signaling networks:
collections of proteins that act as precise biochemical sensors. These protein networks are …

During embryonic development, diffusible signaling molecules called morphogens are
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …