Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

The emergence of proteomics has led to major technological advances in mass
spectrometry (MS). These advancements not only benefitted MS‐based high‐throughput …

All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …

The equilibrium dissociation constant (K d) is a major characteristic of affinity complexes and
one of the most frequently determined physicochemical parameters. Despite its significance …

High throughput protein–ligand interaction screening assays employing mass spectrometric
detection are widely used in early stage drug discovery. Mass spectrometry-based …

Ion mobility–mass spectrometry (IM–MS) is an important addition to the analytical toolbox for
the structural evaluation of proteins, and is enhancing many areas of biophysical analysis …

Analysis of the size and mass of nanoparticles, whether they are natural biomacromolecular
or synthetic supramolecular assemblies, is an important step in the characterization of such …

Human noroviruses (NoVs) are known to recognize histo-blood group antigens (HBGAs) as
attachment factors. We report the first experimental evidence that sialic acid-containing …

Proteins possess an intimate relationship between their structure and function, with folded
protein structures generating recognition motifs for the binding of ligands and other proteins …

The effectiveness of two new supercharging reagents for producing highly charged ions by
electrospray ionization (ESI) from aqueous solutions in which proteins have native structures …