Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

The role of adipose tissue in cardiovascular health and disease

EK Oikonomou, C Antoniades - Nature Reviews Cardiology, 2019 - nature.com
Accumulating knowledge on the biology and function of the adipose tissue has led to a
major shift in our understanding of its role in health and disease. The adipose tissue is now …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

Perivascular adipose tissue and coronary atherosclerosis

J Mancio, EK Oikonomou, C Antoniades - Heart, 2018 - heart.bmj.com
Adipose tissue (AT) is no longer viewed as a passive, energy-storing depot, and a growing
body of evidence supports the concept that both quantitative and qualitative aspects of AT …

Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus

S Yagi, Y Hirata, T Ise, K Kusunose, H Yamada… - Diabetology & metabolic …, 2017 - Springer
Background It is unknown whether canagliflozin, a selective sodium glucose co-transporter
2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with …

Single-cell RNA-sequencing and metabolomics analyses reveal the contribution of perivascular adipose tissue stem cells to vascular remodeling

W Gu, WN Nowak, Y Xie, A Le Bras, Y Hu… - … , and vascular biology, 2019 - Am Heart Assoc
Objective: Perivascular adipose tissue (PVAT) plays a vital role in maintaining vascular
homeostasis. However, most studies ascribed the function of PVAT in vascular remodeling …

The interplay between adipose tissue and the cardiovascular system: is fat always bad?

I Akoumianakis, C Antoniades - Cardiovascular research, 2017 - academic.oup.com
Obesity is a risk factor for cardiovascular disease (CVD). However, clinical research has
revealed a paradoxically protective role for obesity in patients with chronic diseases …

Hypertension induced morphological and physiological changes in cells of the arterial wall

P Martinez-Quinones, CG McCarthy… - American journal of …, 2018 - academic.oup.com
Morphological and physiological changes in the vasculature have been described in the
evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction …

Effect of vessel attenuation, VMI level, and reconstruction kernel on pericoronary adipose tissue attenuation for EID CT and PCD CT: an ex vivo porcine heart study

J Pitteloud, LJ Moser, K Klambauer… - American Journal of …, 2024 - ajronline.org
BACKGROUND. Pericoronary adipose tissue (PCAT) attenuation and the fat attenuation
index (FAI) may serve as markers of inflammation and the risk of adverse cardiac events …

Perivascular adipose tissue in age-related vascular disease

M Queiroz, CM Sena - Ageing research reviews, 2020 - Elsevier
Perivascular adipose tissue (PVAT), a crucial regulator of vascular homeostasis, is actively
involved in vascular dysfunction during aging. PVAT releases various adipocytokines …