Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …
large family of WNT ligands and influencing fundamental biological processes. WNT …
The role of adipose tissue in cardiovascular health and disease
EK Oikonomou, C Antoniades - Nature Reviews Cardiology, 2019 - nature.com
Accumulating knowledge on the biology and function of the adipose tissue has led to a
major shift in our understanding of its role in health and disease. The adipose tissue is now …
major shift in our understanding of its role in health and disease. The adipose tissue is now …
[HTML][HTML] Pathophysiology of obesity and its associated diseases
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …
studies have indicated that obesity strongly contributes to the development of cancer …
Perivascular adipose tissue and coronary atherosclerosis
Adipose tissue (AT) is no longer viewed as a passive, energy-storing depot, and a growing
body of evidence supports the concept that both quantitative and qualitative aspects of AT …
body of evidence supports the concept that both quantitative and qualitative aspects of AT …
Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus
S Yagi, Y Hirata, T Ise, K Kusunose, H Yamada… - Diabetology & metabolic …, 2017 - Springer
Background It is unknown whether canagliflozin, a selective sodium glucose co-transporter
2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with …
2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with …
Single-cell RNA-sequencing and metabolomics analyses reveal the contribution of perivascular adipose tissue stem cells to vascular remodeling
Objective: Perivascular adipose tissue (PVAT) plays a vital role in maintaining vascular
homeostasis. However, most studies ascribed the function of PVAT in vascular remodeling …
homeostasis. However, most studies ascribed the function of PVAT in vascular remodeling …
The interplay between adipose tissue and the cardiovascular system: is fat always bad?
I Akoumianakis, C Antoniades - Cardiovascular research, 2017 - academic.oup.com
Obesity is a risk factor for cardiovascular disease (CVD). However, clinical research has
revealed a paradoxically protective role for obesity in patients with chronic diseases …
revealed a paradoxically protective role for obesity in patients with chronic diseases …
Hypertension induced morphological and physiological changes in cells of the arterial wall
P Martinez-Quinones, CG McCarthy… - American journal of …, 2018 - academic.oup.com
Morphological and physiological changes in the vasculature have been described in the
evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction …
evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction …
Effect of vessel attenuation, VMI level, and reconstruction kernel on pericoronary adipose tissue attenuation for EID CT and PCD CT: an ex vivo porcine heart study
J Pitteloud, LJ Moser, K Klambauer… - American Journal of …, 2024 - ajronline.org
BACKGROUND. Pericoronary adipose tissue (PCAT) attenuation and the fat attenuation
index (FAI) may serve as markers of inflammation and the risk of adverse cardiac events …
index (FAI) may serve as markers of inflammation and the risk of adverse cardiac events …
Perivascular adipose tissue in age-related vascular disease
M Queiroz, CM Sena - Ageing research reviews, 2020 - Elsevier
Perivascular adipose tissue (PVAT), a crucial regulator of vascular homeostasis, is actively
involved in vascular dysfunction during aging. PVAT releases various adipocytokines …
involved in vascular dysfunction during aging. PVAT releases various adipocytokines …