Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …

The identification of MPTP, a relatively simple compound which causes selective
degeneration of the substantia nigra after systemic administration, has had an a significant …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

Parkinson's disease (PD) is a chronic and progressive disorder characterized
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …

Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …

Over the last decade the important concept has emerged that microglia, similar to other
tissue macrophages, assume different phenotypes and serve several effector functions …

There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …