Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …
progression leads to joint deformity and associated loss of function, which significantly …
Targeting transcription factors for therapeutic benefit in rheumatoid arthritis
T Balendran, K Lim, JA Hamilton… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes
pain and disability. Many of the currently available drugs for treating RA patients are aimed …
pain and disability. Many of the currently available drugs for treating RA patients are aimed …
[HTML][HTML] Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway
J Yang, J Liu, J Li, M Jing, L Zhang, M Sun… - International …, 2022 - Elsevier
Objective Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder of the
synovial joints. Celastrol (Cel) is a quinone-methylated triterpenoid extracted from …
synovial joints. Celastrol (Cel) is a quinone-methylated triterpenoid extracted from …
[HTML][HTML] Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization
W Lin, P Shen, Y Huang, L Han, X Ba, Y Huang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Thousands of years of clinical practice in the treatment of
joint-related diseases support the efficacy and safety of Wutou decoction (WTD) …
joint-related diseases support the efficacy and safety of Wutou decoction (WTD) …
[HTML][HTML] Qingre Huazhuo Jiangsuan Decoction promotes autophagy by inhibiting PI3K/AKT/mTOR signaling pathway to relieve acute gouty arthritis
P Liu, Y Xu, J Ye, J Tan, J Hou, Y Wang, J Li… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Gout belongs to the category of" arthralgia syndrome" in
traditional Chinese medicine. It is believed that gout is caused by stagnation of blood stasis …
traditional Chinese medicine. It is believed that gout is caused by stagnation of blood stasis …
Biology of interleukin‑37 and its role in autoimmune diseases
H Zeng, K Zhou, Z Ye - Experimental and Therapeutic …, 2022 - spandidos-publications.com
Autoimmune diseases (AIDs) are characterized by dysfunction and tissue destruction, and
recent studies have shown that interleukin (IL)‑37 expression is dysregulated in AIDs …
recent studies have shown that interleukin (IL)‑37 expression is dysregulated in AIDs …
Environmental pollutants and phosphoinositide signaling in autoimmunity
C Ren, ND Carrillo, VL Cryns, RA Anderson… - Journal of Hazardous …, 2024 - Elsevier
Environmental pollution stands as one of the most critical challenges affecting human
health, with an estimated mortality rate linked to pollution-induced non-communicable …
health, with an estimated mortality rate linked to pollution-induced non-communicable …
B cell metabolism in autoimmune diseases: signaling pathways and interventions
Autoimmune diseases are heterogeneous disorders believed to stem from the immune
system's inability to distinguish between auto-and foreign-antigens. B lymphocytes serve a …
system's inability to distinguish between auto-and foreign-antigens. B lymphocytes serve a …
Research progress in tumor angiogenesis and drug resistance in breast cancer
J Mou, C Li, Q Zheng, X Meng… - Cancer Biology & …, 2024 - pmc.ncbi.nlm.nih.gov
Angiogenesis is considered a hallmark pathophysiological process in tumor development.
Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the …
Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the …
[HTML][HTML] Simiao pill attenuates collagen-induced arthritis and bleomycin-induced pulmonary fibrosis in mice by suppressing the JAK2/STAT3 and TGF-β/Smad2/3 …
X Ba, H Wang, Y Huang, JH Yan, L Han, WJ Lin… - Journal of …, 2023 - Elsevier
Abstract Ethnophamacological relevance Simiao Pill (SM) as a classic prescription of
traditional Chinese medicine treatment of damp-heat arthralgia, the earliest from 'Cheng Fan …
traditional Chinese medicine treatment of damp-heat arthralgia, the earliest from 'Cheng Fan …