Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …

Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
curable in less than 50% of patients. Prognostic models based on pre-treatment …

Galectins are a family of animal lectins with diverse biological activities. They function both
extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and …

Galectins, an ancient lectin family, are characterized by specific binding of β-galactosides
through evolutionary conserved sequence elements of carbohydrate-recognition domain …

Objective—Aldosterone (Aldo) is involved in arterial stiffness and heart failure, but the
mechanisms have remained unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin …

Galectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins
bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular …

Galectin 3 is a member of a family of β-galactoside binding proteins and has emerged as an
important regulator of diverse functions critical in cancer biology including apoptosis …

Many galectin family members are detected primarily intracellularly in most of the systems
studied, although certain members can be found both inside and outside of cells. Specific …

Purpose The role of the microenvironment during the initiation and progression of
carcinogenesis is now realized to be of critical importance, both for enhanced understanding …