Pancreatic cancer is the fourth highest cause of cancer mortality in the world. It has very low
survival rates owing to late diagnosis resulting from the absence of accurate diagnostic tools …

Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive
phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops …

There has been a surge of interest in recent years in understanding the intricate
mechanisms underlying cancer progression and treatment resistance. One molecule that …

Perineural invasion (PNI) is an adverse prognostic feature of pancreatic ductal
adenocarcinoma (PDAC). However, the understanding of the interactions between tumors …

Background & Aims Mucin 13 (MUC13) is reportedly overexpressed in human malignancies.
However, the clinicopathological and biological significance of MUC13 in human …

Abstract Background and Aims There is evidence for a disturbed intestinal barrier function in
inflammatory bowel diseases [IBD] but the underlying mechanisms are unclear. Because …

Clinical and experimental evidence indicates that tumour‐associated macrophages support
cancer progression. Moreover, macrophage‐derived extracellular vesicles (EVs) are …

Many adenocarcinomas, including colorectal cancer (CRC), overexpress the MUC13 cell
surface mucin, but the functional significance and mechanisms are unknown. Here, we …

Ormeloxifene is a clinically approved selective estrogen receptor modulator, which has also
shown excellent anticancer activity, thus it can be an ideal repurposing pharmacophore …

Pancreatic tumors are rewired for high-glucose metabolism and typically present with
exceptionally poor prognosis. Recently, we have shown that MUC13, which is highly …