Imaging the evolution and pathophysiology of Alzheimer disease
W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …
studies of the relationships between the two major proteins deposited in this disease …
Clinical neurology and epidemiology of the major neurodegenerative diseases
MG Erkkinen, MO Kim… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …
older adults. Most clinicians who care for the elderly are not trained to diagnose these …
[HTML][HTML] EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3
The present procedural guidelines summarize the current views of the EANM Neuro-
Imaging Committee (NIC). The purpose of these guidelines is to assist nuclear medicine …
Imaging Committee (NIC). The purpose of these guidelines is to assist nuclear medicine …
[HTML][HTML] Imaging techniques in Alzheimer's disease: a review of applications in early diagnosis and longitudinal monitoring
WM van Oostveen, ECM de Lange - International journal of molecular …, 2021 - mdpi.com
Background. Alzheimer's disease (AD) is a progressive neurodegenerative disorder
affecting many individuals worldwide with no effective treatment to date. AD is characterized …
affecting many individuals worldwide with no effective treatment to date. AD is characterized …
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …
Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities
JM Perez Ortiz, RH Swerdlow - British journal of pharmacology, 2019 - Wiley Online Library
Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …
[HTML][HTML] Brain energy and oxygen metabolism: emerging role in normal function and disease
Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
Plasma phospholipids identify antecedent memory impairment in older adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
[HTML][HTML] The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives
Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …