While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective
pressure, tumor cells show various adaptive characteristics, such as changes in the …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

In mammals, miRNAs recognize target mRNAs via base pairing, which leads to a complex
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …

Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

MicroRNAs (miRs, miRNAs) are small molecules of 18–22 nucleotides that serve as
important regulators of gene expression at the post-transcriptional level. One of the …

The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the
HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by …

The standard treatment for high-grade serous ovarian cancer is primary debulking surgery
followed by chemotherapy. The extent of metastasis and invasive potential of lesions can …