Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Determining the toxicity of chemicals is necessary to identify their harmful effects on humans,
animals, plants, or the environment. It is also one of the main steps in drug design. Animal …

We introduce MetaboAnalyst version 6.0 as a unified platform for processing, analyzing, and
interpreting data from targeted as well as untargeted metabolomics studies using liquid …

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Safety sciences must cope with uncertainty of models and results as well as information
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …

The exposome encompasses an individual's exposure to exogenous chemicals, as well as
endogenous chemicals that are produced or altered in response to external stressors. While …

Metabolomics is a widely used technology in academic research, yet its application to
regulatory science has been limited. The most commonly cited barrier to its translation is …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Consumer and environmental safety decisions are based on exposure and hazard data,
interpreted using risk assessment approaches. The adverse outcome pathway (AOP) …

Since March 2013, animal use for cosmetics testing for the European market has been
banned. This requires a renewed view on risk assessment in this field. However, in other …