Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Abstract DNMT1 (DNA methyltransferase 1) is the predominant member of the DNMT family
and the most abundant DNMT in various cell types. It functions as a maintenance DNMT and …

At the end of the 20th century, analog systems in computer science have been widely
replaced by digital systems due to their higher computing power. Nevertheless, the question …

The maintenance of epigenetic characteristics is essential for the normal growth and
development of organisms. The maintenance of DNA methylation is an important way to …

Epilepsy is a common neurological disorder characterized by recurrent seizures with
excessive and abnormal neuronal discharges. Epileptogenesis is usually involved in …

Social deprivation can be stressful for group-living mammals. On the other hand, an
amazing response of these animals to stress is seeking social contact to give and receive …

DNA methyltransferases (DNMTs) are widely expressed in the brain, dictating the
transcriptional activity of genes through various epigenetic mechanisms. Functional …

Epigenetic mechanisms are emerging key players for the regulation of brain function,
synaptic activity, and the formation of neuronal engrams in health and disease. As one …

Increased life expectancy in modern society comes at the cost of age-associated disabilities
and diseases. Aged brains not only show reduced excitability and plasticity, but also a …

The limited regenerative capacity of neurons requires a tightly orchestrated cell death and
survival regulation in the context of longevity, as well as age-associated and …