Clinical consequences of developmental programming of low nephron number

VA Luyckx, BM Brenner - The Anatomical Record, 2020 - Wiley Online Library
Nephron number in humans varies up to 13‐fold, likely reflecting the impact of multiple
factors on kidney development, including inherited body size and ethnicity, as well as …

Nonhuman primates in translational research

AF Tarantal, SC Noctor… - Annual review of …, 2022 - annualreviews.org
Nonhuman primates are critically important animal models in which to study complex human
diseases, understand biological functions, and address the safety of new diagnostics and …

Polycystic ovary syndrome: challenges and possible solutions

Y Che, J Yu, YS Li, YC Zhu, T Tao - Journal of Clinical Medicine, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in
women of reproductive age. This syndrome not only impairs female fertility but also …

Back to normal? Building community resilience after COVID-19

M Penkler, R Müller, M Kenney… - The Lancet Diabetes & …, 2020 - thelancet.com
Although the COVID-19 pandemic is far from over, many countries are resuming economic
and social activities, with the aim of returning to some semblance of normality. But what …

Pressures of the urban environment on the endocrine system: adverse effects and adaptation

P Rannaud-Bartaire, BA Demeneix, JB Fini - Molecular and Cellular …, 2024 - Elsevier
With an increasing collective awareness of the rapid environmental changes, questions and
theories regarding the adaptability of organisms are emerging. Global warming as well as …

Epigenetic biomarkers for disease susceptibility and preventative medicine

MK Skinner - Cell metabolism, 2024 - cell.com
The development of molecular biomarkers for disease makes it possible for preventative
medicine approaches to be considered. Therefore, therapeutics, treatments, or clinical …

Contrasted life trajectories: reconstituting the main population exposomes in French Guiana

M Nacher, C Basurko, M Douine, Y Lambert… - Frontiers in Public …, 2024 - frontiersin.org
In French Guiana, life expectancy is between 2 and 3 years below that of France, reflecting
differences in mortality rates that are largely sensitive to primary healthcare and thus …

Understanding the importance of the early-life period for adult health: a systematic review

JR Hildreth, MH Vickers, T Buklijas… - Journal of Developmental …, 2023 - cambridge.org
Evidence clearly indicates that the nutritional and non-nutritional environment and level of
physical activity during the early-life period from preconception through infancy has a …

Mitochondrial DNA copy number and developmental origins of health and disease (DOHaD)

H Fukunaga - International Journal of Molecular Sciences, 2021 - mdpi.com
Mitochondrial dysfunction is known to contribute to mitochondrial diseases, as well as to a
variety of aging-based pathologies. Mitochondria have their own genomes (mitochondrial …

Dissecting human placental cells heterogeneity in preeclampsia and gestational diabetes using single-cell sequencing

B Jiao, Y Wang, S Li, J Lu, J Liu, J Xia, Y Li, J Xu… - Molecular …, 2023 - Elsevier
Preeclampsia (PE) and gestational diabetes mellitus (GDM) are pregnancy-specific
complications, which affect maternal health and fetal outcomes. Currently, clinical and …