Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

Multiple pathways are involved in maintaining the genetic integrity of a cell after its exposure
to ionizing radiation. Although repair mechanisms such as homologous recombination and …

BRCA1 (BReast‐CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the
mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research …

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by
promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 …

Germline mutations of the breast cancer associated gene 1 (BRCA1) predispose women to
breast and ovarian cancers. BRCA1 is a large protein with multiple functional domains and …

The Brca1 (breast cancer gene 1) tumor suppressor protein is phosphorylated in response
to DNA damage. Results from this study indicate that the checkpoint protein kinase ATM …

Rationale: Inducing cancer differentiation is a promising approach to treat cancer. Here, we
identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and …

Ataxia telangiectasia mutated (ATM) phosphorylates p53 protein in response to ionizing
radiation, but the complex phenotype of AT cells suggests that it must have other cellular …