Purpose. Although oral delivery has become a widely accepted route of administration of
therapeutic drugs, the gastrointestinal tract presents several formidable barriers to drug …

Colon specific drug delivery has gained increased importance not just for the delivery of
drugs for the treatment of local diseases associated with the colon but also as potential site …

Microencapsulation has been developed by the pharmaceutical industry as a means to
control or modify the release of drug substances from drug delivery systems. In drug delivery …

Oral drug delivery to the colon has attracted significant attention during the past 20 years.
Colon targeting is recognised to have several therapeutic advantages, such as the oral …

The aim of this study was to investigate extrusion–spheronization pelletization for preparing
pH-sensitive matrix pellets for colon-specific drug delivery. The effects of three independent …

Oral colon-specific drug-delivery systems have recently gained importance for delivering a
variety of therapeutic agents. The major obstacles to delivering drugs to the colon are the …

Hot-melt extruded tablets were prepared using Eudragit® S 100 as the polymeric carrier to
target delivery of 5-aminosalicylic acid (5-ASA) to the colon. Scanning electron microscopy …

Oral colon delivery is pursued through a number of formulation strategies with the aim of
enabling effective and well-tolerated treatments for large bowel pathologies or enhancing …

In the last two decades colon targeted drug delivery has gained increased importance not
just for the deliver drugs for the treatment of various colonic diseases but also for its potential …

Most pH-sensitive polymer coating studies for potential colonic delivery systems apply
multiple layers to protect the active agent from degradation and early release in the stomach …