Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
Public health emergencies of international concern: a historic overview
A Wilder-Smith, S Osman - Journal of travel medicine, 2020 - academic.oup.com
Abstract Rationale The International Health Regulations (IHR) have been the governing
framework for global health security since 2007. Declaring public health emergencies of …
framework for global health security since 2007. Declaring public health emergencies of …
[HTML][HTML] Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure
Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new
platform to investigate human brain development. High cost, variability, and tissue …
platform to investigate human brain development. High cost, variability, and tissue …
Zika virus infects human cortical neural progenitors and attenuates their growth
The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and
microcephaly is an urgent global health concern. The direct target cells of ZIKV in the …
microcephaly is an urgent global health concern. The direct target cells of ZIKV in the …
Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study
S Cauchemez, M Besnard, P Bompard, T Dub… - The Lancet, 2016 - thelancet.com
Summary Background The emergence of Zika virus in the Americas has coincided with
increased reports of babies born with microcephaly. On Feb 1, 2016, WHO declared the …
increased reports of babies born with microcephaly. On Feb 1, 2016, WHO declared the …
Epidemic arboviral diseases: priorities for research and public health
For decades, arboviral diseases were considered to be only minor contributors to global
mortality and disability. As a result, low priority was given to arbovirus research investment …
mortality and disability. As a result, low priority was given to arbovirus research investment …
[HTML][HTML] Zika virus disrupts neural progenitor development and leads to microcephaly in mice
The link between Zika virus (ZIKV) infection and microcephaly has raised urgent global
alarm. The historical African ZIKV MR766 was recently shown to infect cultured human …
alarm. The historical African ZIKV MR766 was recently shown to infect cultured human …
Phototactic guidance of a tissue-engineered soft-robotic ray
Inspired by the relatively simple morphological blueprint provided by batoid fish such as
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …
Human iPSC-derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia
M Bershteyn, TJ Nowakowski, AA Pollen, E Di Lullo… - Cell stem cell, 2017 - cell.com
Classical lissencephaly is a genetic neurological disorder associated with mental
retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe …
retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe …
Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy
The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …