The physiology, pathology, and potential therapeutic applications of the TREM2 signaling pathway
Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading
causes of death and among the most costly medical conditions in the Western world. In all …
causes of death and among the most costly medical conditions in the Western world. In all …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation
There is currently little information available about how individual cell types contribute to
Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …
Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's …
We developed an endophenotype disease module-based methodology for Alzheimer's
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …
Reprogramming roadmap reveals route to human induced trophoblast stem cells
X Liu, JF Ouyang, FJ Rossello, JP Tan, KC Davidson… - Nature, 2020 - nature.com
The reprogramming of human somatic cells to primed or naive induced pluripotent stem
cells recapitulates the stages of early embryonic development,,,,–. The molecular …
cells recapitulates the stages of early embryonic development,,,,–. The molecular …
The type and source of reactive oxygen species influences the outcome of oxidative stress in cultured cells
Oxidative stress can be modeled using various different experimental approaches, such as
exposing the cells or organisms to oxidative chemicals. However, the actual effects of these …
exposing the cells or organisms to oxidative chemicals. However, the actual effects of these …
[HTML][HTML] Transcriptome and proteome profiling of primary human gastric interstitial cells of Cajal predicts pacemaker networks
D Foong, M Mikhael, J Zhou, A Zarrouk… - Journal of …, 2023 - ncbi.nlm.nih.gov
Methods Excess human gastric tissue resections were obtained from sleeve gastrectomy
patients. ICC were purified using fluorescence-activated cell sorting (FACSorting). Then, ICC …
patients. ICC were purified using fluorescence-activated cell sorting (FACSorting). Then, ICC …
A consensus proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of the biological changes in the brain associated with Alzheimer's
disease (AD) pathology and cognitive impairment remains incomplete. To increase our …
disease (AD) pathology and cognitive impairment remains incomplete. To increase our …
Determinants of macrophage and neutrophil heterogeneity in cardiac repair after myocardial infarction
G Rizzo - 2023 - opus.bibliothek.uni-wuerzburg.de
Current therapeutic strategies efficiently improve survival in patients after myocardial
infarction (MI). Nevertheless, long-term consequences such as heart failure development …
infarction (MI). Nevertheless, long-term consequences such as heart failure development …