Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

PC Calder - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Inflammation is a condition which contributes to a range of human diseases. It involves a
multitude of cell types, chemical mediators, and interactions. Eicosapentaenoic acid (EPA) …

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

SC Dyall - Frontiers in aging neuroscience, 2015 - frontiersin.org
Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and
represent a potential treatment for a variety of neurodegenerative and neurological …

[HTML][HTML] Nuclear receptors, RXR, and the big bang

RM Evans, DJ Mangelsdorf - Cell, 2014 - cell.com
Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …

Docosahexaenoic acid and cognition throughout the lifespan

MJ Weiser, CM Butt, MH Mohajeri - Nutrients, 2016 - mdpi.com
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid
(PUFA) found in the brain and can affect neurological function by modulating signal …

Perilipins: a diversity of intracellular lipid droplet proteins

H Itabe, T Yamaguchi, S Nimura, N Sasabe - Lipids in health and disease, 2017 - Springer
Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been
recognized as organelles with unique spherical structures. Although LDs are not stable lipid …

Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events

D Mozaffarian, JHY Wu - Journal of the American College of Cardiology, 2011 - jacc.org
We reviewed available evidence for cardiovascular effects of n-3 polyunsaturated fatty acid
(PUFA) consumption, focusing on long chain (seafood) n-3 PUFA, including their principal …

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

CN Serhan, S Hong, K Gronert, SP Colgan… - The Journal of …, 2002 - rupress.org
Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase
(COX)-2 enabling the biosynthesis of R-containing precursors of endogenous …

The opposing effects of n− 3 and n− 6 fatty acids

G Schmitz, J Ecker - Progress in lipid research, 2008 - Elsevier
Polyunsaturated fatty acids (PUFAs) can be classified in n− 3 fatty acids and n− 6 fatty acids,
and in westernized diet the predominant dietary PUFAs are n− 6 fatty acids. Both types of …

Nuclear receptors and lipid physiology: opening the X-files

A Chawla, JJ Repa, RM Evans, DJ Mangelsdorf - Science, 2001 - science.org
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only
nutritionally important but serve as precursors for ligands that bind to receptors in the …