Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects

Q Liu, J Tang, S Chen, S Hu, C Shen, J Xiang… - Pharmacological …, 2022 - Elsevier
Gastric carcinoma (GC) is a complex multifactorial disease occurring as sequential events
commonly referred to as the Correa's cascade, a stepwise progression from non-active or …

[HTML][HTML] Drug discovery of sclerostin inhibitors

S Yu, D Li, N Zhang, S Ni, M Sun, L Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …

Upregulated-gene expression of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) via TLRs following NF-κB and MAPKs in bovine mastitis

M Akhtar, S Guo, Y Guo, A Zahoor, A Shaukat, Y Chen… - Acta tropica, 2020 - Elsevier
Mastitis is the inflammation of mammary glands which causes huge economic loss in dairy
cows. Inflammation, any tissue injury and pathogens in cow udder activate Toll-like …

Ameliorating and protective effects mesalazine on ethanol-induced gastric ulcers in experimental rats

M Beiranvand, S Bahramikia - European Journal of Pharmacology, 2020 - Elsevier
Gastric ulcer is a frequent gastrointestinal tract (GIT) disorder that affects about 10% of the
world population. Drug candidates that can provide high efficacy and low toxicity are needed …

[HTML][HTML] Rutaecarpine ameliorates ethanol-induced gastric mucosal injury in mice by modulating genes related to inflammation, oxidative stress and apoptosis

S Ren, Y Wei, R Wang, S Wei, J Wen, T Yang… - Frontiers in …, 2020 - frontiersin.org
Background: Rutaecarpine (RUT), a major quinazolino carboline alkaloid compound from
the dry unripe fruit Tetradium ruticarpum (A. Juss.) TG Hartley, has various pharmacological …

Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular …

SA Salama, AM Kabel - Chemico-biological interactions, 2020 - Elsevier
Although physiological levels of iron are essential for numerous biological processes,
excess iron causes critical tissue injury. Under iron overload conditions, non-chelated iron …

[HTML][HTML] Protective effects of wheat peptides against ethanol-induced gastric mucosal lesions in rats: vasodilation and anti-inflammation

L Yu, R Li, W Liu, Y Zhou, Y Li, Y Qin, Y Chen, Y Xu - Nutrients, 2020 - mdpi.com
Alcohol consumption increases the risk of gastritis and gastric ulcer. Nutritional alternatives
are considered for relieving the progression of gastric mucosal lesions instead of …

Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway

Y Wu, Z Duan, L Qu, Y Zhang, C Zhu, D Fan - Food & Function, 2023 - pubs.rsc.org
Ginsenoside Rh4, a bioactive component extracted from Panax ginseng, exhibits various
pharmacological activities, such as anti-inflammatory, anti-oxidation, anti-diabetes, anti …

Irbesartan reprofiling for the amelioration of ethanol-induced gastric mucosal injury in rats: Role of inflammation, apoptosis, and autophagy

HH Arab, AH Eid, AAK El-Sheikh, ESA Arafa… - Life Sciences, 2022 - Elsevier
Background Pronounced anti-inflammatory and anti-apoptotic features have been
characterized for the angiotensin receptor blocker irbesartan. Yet, its effect on ethanol …

Protective effects of radix sophorae flavescentis carbonisata-based carbon dots against ethanol‐induced acute gastric ulcer in rats: anti-inflammatory and antioxidant …

J Hu, J Luo, M Zhang, J Wu, Y Zhang… - International Journal …, 2021 - Taylor & Francis
Aim To explore the effects of Radix Sophorae Flavescentis carbonisata-based carbon dots
(RSFC-CDs) on an ethanol-induced acute gastric ulcer rat model. Methods The structure …