Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects
Q Liu, J Tang, S Chen, S Hu, C Shen, J Xiang… - Pharmacological …, 2022 - Elsevier
Gastric carcinoma (GC) is a complex multifactorial disease occurring as sequential events
commonly referred to as the Correa's cascade, a stepwise progression from non-active or …
commonly referred to as the Correa's cascade, a stepwise progression from non-active or …
[HTML][HTML] Drug discovery of sclerostin inhibitors
S Yu, D Li, N Zhang, S Ni, M Sun, L Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …
Upregulated-gene expression of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) via TLRs following NF-κB and MAPKs in bovine mastitis
Mastitis is the inflammation of mammary glands which causes huge economic loss in dairy
cows. Inflammation, any tissue injury and pathogens in cow udder activate Toll-like …
cows. Inflammation, any tissue injury and pathogens in cow udder activate Toll-like …
Ameliorating and protective effects mesalazine on ethanol-induced gastric ulcers in experimental rats
M Beiranvand, S Bahramikia - European Journal of Pharmacology, 2020 - Elsevier
Gastric ulcer is a frequent gastrointestinal tract (GIT) disorder that affects about 10% of the
world population. Drug candidates that can provide high efficacy and low toxicity are needed …
world population. Drug candidates that can provide high efficacy and low toxicity are needed …
[HTML][HTML] Rutaecarpine ameliorates ethanol-induced gastric mucosal injury in mice by modulating genes related to inflammation, oxidative stress and apoptosis
S Ren, Y Wei, R Wang, S Wei, J Wen, T Yang… - Frontiers in …, 2020 - frontiersin.org
Background: Rutaecarpine (RUT), a major quinazolino carboline alkaloid compound from
the dry unripe fruit Tetradium ruticarpum (A. Juss.) TG Hartley, has various pharmacological …
the dry unripe fruit Tetradium ruticarpum (A. Juss.) TG Hartley, has various pharmacological …
Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular …
Although physiological levels of iron are essential for numerous biological processes,
excess iron causes critical tissue injury. Under iron overload conditions, non-chelated iron …
excess iron causes critical tissue injury. Under iron overload conditions, non-chelated iron …
[HTML][HTML] Protective effects of wheat peptides against ethanol-induced gastric mucosal lesions in rats: vasodilation and anti-inflammation
L Yu, R Li, W Liu, Y Zhou, Y Li, Y Qin, Y Chen, Y Xu - Nutrients, 2020 - mdpi.com
Alcohol consumption increases the risk of gastritis and gastric ulcer. Nutritional alternatives
are considered for relieving the progression of gastric mucosal lesions instead of …
are considered for relieving the progression of gastric mucosal lesions instead of …
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway
Y Wu, Z Duan, L Qu, Y Zhang, C Zhu, D Fan - Food & Function, 2023 - pubs.rsc.org
Ginsenoside Rh4, a bioactive component extracted from Panax ginseng, exhibits various
pharmacological activities, such as anti-inflammatory, anti-oxidation, anti-diabetes, anti …
pharmacological activities, such as anti-inflammatory, anti-oxidation, anti-diabetes, anti …
Irbesartan reprofiling for the amelioration of ethanol-induced gastric mucosal injury in rats: Role of inflammation, apoptosis, and autophagy
Background Pronounced anti-inflammatory and anti-apoptotic features have been
characterized for the angiotensin receptor blocker irbesartan. Yet, its effect on ethanol …
characterized for the angiotensin receptor blocker irbesartan. Yet, its effect on ethanol …
Protective effects of radix sophorae flavescentis carbonisata-based carbon dots against ethanol‐induced acute gastric ulcer in rats: anti-inflammatory and antioxidant …
J Hu, J Luo, M Zhang, J Wu, Y Zhang… - International Journal …, 2021 - Taylor & Francis
Aim To explore the effects of Radix Sophorae Flavescentis carbonisata-based carbon dots
(RSFC-CDs) on an ethanol-induced acute gastric ulcer rat model. Methods The structure …
(RSFC-CDs) on an ethanol-induced acute gastric ulcer rat model. Methods The structure …