While cisplatin and carboplatin are active versus most common cancers, epithelial
malignancies are incurable when metastatic. Even if an initial response occurs, acquired …

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …

Objective Ovarian cancer is the deadliest gynaecological cancer. A major contributor to the
poor survival rate is the development of chemoresistance to platinum-based therapies such …

Dasatinib is a multitargeted kinase inhibitor that was recently approved for the treatment of
chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic …

Ovarian carcinoma is a lethal gynecological malignancy. Women with ovarian cancer (OC)
are highly recurrent and typically diagnosed at late stage. Ten-eleven translocation protein 3 …

Abstract l-Asparaginase (l-ASP), a bacterial enzyme used since the 1970s to treat acute
lymphoblastic leukemia, selectively starves cells that cannot synthesize sufficient …

Ovarian cancers have a high mortality rate; this is in part due to resistance to the platinum-
based compounds used in chemotherapy. In this paper, we assess the role of microRNA-31 …

Malignant tumors have a high glucose demand and alter cellular metabolism to survive.
Herein, focusing on the utility of glucose metabolism as a therapeutic target, we found that …

Despite advances in radical surgery and chemotherapy delivery, ovarian cancer is the most
lethal gynecologic malignancy. Standard therapy includes treatment with platinum-based …

Mutations of the p53 gene hallmark many human cancers. Several p53 mutant proteins
acquire the capability to promote cancer progression and metastasis, a phenomenon …