Current scientific debates center on the impact of lipids and mitochondrial function on
diverse aspects of human health, nutrition and disease, among them the association of …

Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and
how these characteristics may be exploited as therapeutic targets. Much attention has …

Although incidence and prevalence of prediabetes are increasing, little is known about its
cardiac effects. Therefore, our aim was to investigate the effect of prediabetes on cardiac …

Cardiovascular disease (CVD), including heart failure, constitutes the main source of
morbidity and mortality in men and women with diabetes. Although healthy young women …

Type 2 diabetes and obesity are associated with systemic inflammation, generalized
enlargement of fat depots, and uncontrolled release of fatty acids (FA) into the circulation …

Elevations in circulating levels of branched-chain amino acids (BCAAs) are associated with
a variety of cardiometabolic diseases and conditions. Restriction of dietary BCAAs in rodent …

Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a
strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) …

The bile salt export pump (BSEP) is an ATP-binding cassette transporter that serves as the
primary system for removing bile salts from the liver. In humans, deficiency of BSEP, which is …

Transmission electron microscopy (TEM) has long been an important technique, capable of
high degree resolution and visualization of subcellular structures and organization. Over the …

It is well established that the heart is strongly dependent on fatty acid metabolism. In
cardiomyocytes there are two distinct sites for the β-oxidisation of fatty acids: the …