Epigenetics and aging
S Pal, JK Tyler - Science advances, 2016 - science.org
Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …
to epigenetic information accompany aging in both dividing and nondividing cells …
Lateral thinking: how histone modifications regulate gene expression
M Lawrence, S Daujat, R Schneider - Trends in Genetics, 2016 - cell.com
The DNA of each cell is wrapped around histone octamers, forming so-called 'nucleosomal
core particles'. These histone proteins have tails that project from the nucleosome and many …
core particles'. These histone proteins have tails that project from the nucleosome and many …
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
S Ramazi, A Allahverdi, J Zahiri - Journal of biosciences, 2020 - Springer
Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
Histone chaperone networks shaping chromatin function
CM Hammond, CB Strømme, H Huang… - … reviews Molecular cell …, 2017 - nature.com
The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …
oligomerization, post-translational modification, nuclear import, stability, assembly and …
Histone core modifications regulating nucleosome structure and dynamics
P Tessarz, T Kouzarides - Nature reviews Molecular cell biology, 2014 - nature.com
Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …
replication, transcription and repair. These modifications function as platforms for the …
Comprehensive catalog of currently documented histone modifications
Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …
proteomics have identified a large number of novel histone posttranslational modifications …
[HTML][HTML] Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
X Gao, SH Lin, F Ren, JT Li, JJ Chen, CB Yao… - Nature …, 2016 - nature.com
Besides the conventional carbon sources, acetyl-CoA has recently been shown to be
generated from acetate in various types of cancers, where it promotes lipid synthesis and …
generated from acetate in various types of cancers, where it promotes lipid synthesis and …
Post-translational modifications of histones that influence nucleosome dynamics
GD Bowman, MG Poirier - Chemical reviews, 2014 - ACS Publications
Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
[HTML][HTML] Chromatin modifications and their function
T Kouzarides - Cell, 2007 - cell.com
The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been …
different classes have been characterized to date and many different sites have been …
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
The decision by a cell to enter a round of growth and division must be intimately coordinated
with nutrient availability and its metabolic state. These metabolic and nutritional …
with nutrient availability and its metabolic state. These metabolic and nutritional …