TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

Megalocornea and anterior megalophthalmos (megalocornea spectrum) disorders are
typically defined by corneal diameter> 12.5 mm in the absence of elevated intraocular …

Using small molecule drugs to treat eye diseases carries benefits of specificity, scalability,
and transportability, but their efficacy is significantly limited by a fast intraocular clearance …

Background Accumulating evidence suggests that dysregulation of Chordin-like 1
(CHRDL1) is associated with malignant biological behaviors in multiple cancers. However …

Abstract Chordin-like 1 (CHRDL1), an inhibitor of bone morphogenetic proteins (BMPs), has
been recently reported to participate in the progression of numerous tumors, however, its …

Epithelial fusion underlies many vital organogenic processes during embryogenesis.
Disruptions to these cause a significant number of human birth defects, including ocular …

Background Methylation at cytosines (mCG) is a well-known regulator of gene expression,
but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied …

Childhood glaucoma is a heterogeneous disease and can be associated with various
genetic alterations. The aim of this study was to report first results of the phenotype …

Animal models have contributed greatly to our understanding of human diseases. Here, we
focus on cornea epithelial stem cell (CESC) deficiency (commonly called limbal stem cell …

Studies of Xenopus eye development have contributed considerably to the understanding of
vertebrate neurogenesis, including eye field specification, cell fate determination and …