The extensive polymorphism of KIR genes

D Middleton, F Gonzelez - Immunology, 2010 - Wiley Online Library
The functions of human natural killer (NK) cells are controlled by diverse families of antigen
receptors. Prominent among these are the killer cell immunoglobulin‐like receptors (KIR), a …

The killer cell immunoglobulin‐like receptor (KIR) genomic region: gene‐order, haplotypes and allelic polymorphism

KC Hsu, S Chida, DE Geraghty… - Immunological …, 2002 - Wiley Online Library
Recent genetic studies have established that the killer cell immunoglobulin‐like receptor
(KIR) genomic region displays extensive diversity through variation in gene content and …

Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success

SE Hiby, JJ Walker, KM O'shaughnessy… - The Journal of …, 2004 - rupress.org
Preeclampsia is a serious complication of pregnancy in which the fetus receives an
inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the …

Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes

KC Hsu, CA Keever-Taylor, A Wilton, C Pinto, G Heller… - Blood, 2005 - ashpublications.org
Inhibitory killer immunoglobulin (Ig)-like receptors (KIRs) recognize HLA-C and-B epitopes
on target cells, thereby regulating natural killer (NK) cell activity. In 178 patients receiving T …

Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple …

KC Hsu, XR Liu, A Selvakumar, E Mickelson… - The journal of …, 2002 - journals.aai.org
Killer Ig-like receptor (KIR) genes constitute a multigene family whose genomic diversity is
achieved through differences in gene content and allelic polymorphism. KIR haplotypes …

The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense

AA Bashirova, MP Martin, DW McVicar… - Annu. Rev. Genomics …, 2006 - annualreviews.org
Killer immunoglobulin-like receptors (KIRs) are molecules expressed on the surface of
natural killer (NK) cells, which play an important role in innate immunity. KIR recognition of …

KIR and disease: a model system or system of models?

SI Khakoo, M Carrington - Immunological reviews, 2006 - Wiley Online Library
The discovery of an unexpected level of diversity among the killer cell immunoglobulin‐like
receptors has led to a search for their role in human disease. Due to their polymorphism and …

Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype

HG Shilling, LA Guethlein, NW Cheng… - The Journal of …, 2002 - journals.aai.org
Killer Ig-like receptor (KIR) genes are a multigene family on human chromosome 19. KIR
genes occur in various combinations on different haplotypes. Additionally, KIR genes are …

Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes

M Uhrberg, P Parham, P Wernet - Immunogenetics, 2002 - Springer
The segregation of killer cell immunoglobulin-like receptor (KIR) genes was determined for a
panel of 21 Caucasoid families: 23 different KIR gene patterns were found and could be …

Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR)

AK Purdy, KS Campbell - Cancer biology & therapy, 2009 - Taylor & Francis
Natural killer (NK) cells are innate immune effector cells that make up~ 10-15% of the
peripheral blood lymphocytes in humans and are primarily involved in immunosurveillance …