A review of the therapeutic importance of indole scaffold in drug discovery
Indole is known as a versatile heterocyclic building block for its multiple pharmacological
activities and has a high probability of success in the race for drug candidates. Many natural …
activities and has a high probability of success in the race for drug candidates. Many natural …
Role of natural and synthetic flavonoids as potential aromatase inhibitors in breast cancer: structure-activity relationship perspective
World Health Organization categorized breast cancer as one of the leading cancer types in
females worldwide, and its treatment remains challenging. Accumulated evidence …
females worldwide, and its treatment remains challenging. Accumulated evidence …
Flavonoids as promising anticancer agents: an in silico investigation of ADMET, binding affinity by molecular docking and molecular dynamics simulations
Cancer is one of the most concerning diseases to humankind. Various treatment strategies
are being employed for its treatment, out of which use of natural products is an essential …
are being employed for its treatment, out of which use of natural products is an essential …
Impact of Some Natural and Artificial Sweeteners Consumption on Different Hormonal Levels and Inflammatory Cytokines in Male Rats: In Vivo and In Silico Studies
Substituting sugar with noncaloric sweeteners prevents overweight and diabetes
development. They come in two types: artificial, like aspartame and sucralose, and natural …
development. They come in two types: artificial, like aspartame and sucralose, and natural …
Identification of chalcone derivatives as putative non-steroidal aromatase inhibitors potentially useful against breast cancer by molecular docking and ADME …
Aromatase is an influential target to overcome estrogen receptor positive breast cancer, as
the enzyme is responsible for conversion of androstenedione to estrone, a promising drug …
the enzyme is responsible for conversion of androstenedione to estrone, a promising drug …
In Vitro Cytotoxicity and Aromatase Inhibitory Activity of Flavonoids: Synthesis, Molecular Docking and In Silico ADME Prediction
Background: Many natural and synthetic flavonoids have been studied and documented by
inhibiting aromatase enzymes for their anti-cancer activity against breast carcinoma. The …
inhibiting aromatase enzymes for their anti-cancer activity against breast carcinoma. The …
[PDF][PDF] Designing of promising Tromethamine-Diflunisal-Pyrrole combinations based on COX binding, drug-properties and safety
MP Nambiar, B AR - … Journal of Biochemistry and Biophysics (IJBB …, 2022 - op.niscpr.res.in
Gastric issues that accompany the use of NSAIDs (Non-steroid anti-inflammatory drugs) are
always a serious global concern. The inhibition of the Cycloxygenase enzyme (COX) limits …
always a serious global concern. The inhibition of the Cycloxygenase enzyme (COX) limits …
Molecular docking, synthesis and biological evaluation of sulphonylureas/guanidine derivatives as promising antidiabetic agent
Background: A series of novel sulphonylureas/guanidine derivatives was designed,
synthesized, and evaluated for the treatment of diabetes mellitus. In this study, the designed …
synthesized, and evaluated for the treatment of diabetes mellitus. In this study, the designed …
[PDF][PDF] Structure-based drug designing, scoring, and synthesis of some substituted sulphonylureas/guanidine-based derivatives as hypoglycemic agents
Objective: The present work deals with the designing, scoring, synthesis and,
characterization of 1-(4-(2-(4-Substitutedphenylamino)-2-oxoethyl) phenylsulfonyl)-3-(4 …
characterization of 1-(4-(2-(4-Substitutedphenylamino)-2-oxoethyl) phenylsulfonyl)-3-(4 …