The United States is in an era of unprecedented levels of drug-related mortality, evidenced
by an exponential increase in deaths over a recent 38-year period. 1 The recent drivers of …

The current overdose and broader public health crisis involving illicit drug use is often
referred to as the “opioid” or “fentanyl” crisis. Clearly there is extensive data on the profound …

Background Substance misuse is a heterogeneous and complex set of behavioural
conditions that are highly prevalent in hospital settings and frequently co-occur. Few hospital …

Background Methamphetamine use is a growing public health concern in the United States.
Prior analyses with nationally representative data from 2015 to 2017 suggested that …

Enkephalin, an endogenous opioid peptide, is highly expressed in the reward pathway and
may modulate neurotransmission to regulate reward-related behaviors, such as drug-taking …

Methamphetamine use is increasing among people who use opioids (PWUO); however,
factors associated with methamphetamine use among PWUO have not been systematically …

Introduction Rising rates of methamphetamine use among populations using opioids is an
escalating public health concern. The purpose of this manuscript is to identify socioecologic …

Background This meta-analysis (PROSPERO-ID: CRD42022362962), pooled effect
estimates of outcomes, from placebo-controlled randomized clinical trials (RCTs) examining …

Objective: There is an increase in persons entering substance use treatment who co-use
opioids and methamphetamines in recent years. Co-using these substances may negatively …

The co-occurrence of substance use disorders (SUDs) and psychiatric conditions, often
referred to as comorbidity or concurrent disorders, presents intricate challenges in both …