Systemic sclerosis (SSc) is a systemic autoimmune disease affecting multiple organ
systems, including the lungs. Interstitial lung disease (ILD) is the leading cause of death in …

Systemic sclerosis (SSc), also referred to as systemic scleroderma or scleroderma, is a rare,
complex immune-mediated connective tissue disease characterized by progressive skin …

Objective To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical
practice. Methods We performed a prospective study including patients with SSc from the …

Background Preliminary criteria for the very early diagnosis of systemic sclerosis (VEDOSS)
have been previously proposed to identify signs and symptoms in patients with Raynaud's …

Objectives Determine global skin transcriptome patterns of early diffuse systemic sclerosis
(SSc) and how they differ from later disease. Methods Skin biopsy RNA from 48 patients in …

Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative
alterations of the microvasculature leading to fibrosis and loss of function of the skin and …

Systemic sclerosis (SSc) has the highest cause-specific mortality of all the connective tissue
diseases, and the aetiology of this complex and heterogeneous condition remains an …

Interstitial lung disease (ILD) has been recognized as a frequent manifestation associated
with a substantial morbidity and mortality burden in patients with autoimmune rheumatic …

Autoimmune diseases recognize a multifactorial pathogenesis, although the exact
mechanism responsible for their onset remains to be fully elucidated. Over the past few …

Objectives Riociguat is approved for pulmonary arterial hypertension and has
antiproliferative, anti-inflammatory and antifibrotic effects in animal models of tissue fibrosis …