Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Human skin and hair color are visible traits that can vary dramatically within and across
ethnic populations. The genetic makeup of these traits—including polymorphisms in the …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …

Skin color is highly variable in Africans, yet little is known about the underlying molecular
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …

We report a genome-wide association scan in> 6,000 Latin Americans for pigmentation of
skin and eyes. We found eighteen signals of association at twelve genomic regions. These …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Abstract Forensic DNA Phenotyping (FDP) comprises the prediction of a person's externally
visible characteristics regarding appearance, biogeographic ancestry and age from DNA of …

Human eye color is highly heritable, but its genetic architecture is not yet fully understood.
We report the results of the largest genome-wide association study for eye color to date …

The genome-wide association study (GWAS) is an effective method to detect single-
nucleotide polymorphisms (SNPs) of multiple individual genes based on linkage …