The cells of organisms as diverse as bacteria and humans can enter stable, nonproliferating
quiescent states. Quiescent cells of eukaryotic and prokaryotic microorganisms can survive …

Recent years have seen a rise in publications demonstrating coupling between transcription
and mRNA decay. This coupling most often accompanies cellular processes that involve …

Little is known about crosstalk between the eukaryotic transcription and translation
machineries that operate in different cell compartments. The yeast proteins Rpb4p and …

It is commonly appreciated that the mRNA level is determined by the balance between its
synthetic and decay kinetics. Yet, little is known about coordination between these distinct …

Maintaining appropriate mRNAs levels is vital for any living cell. mRNA synthesis in the
nucleus by RNA polymerase II core enzyme (Pol II) and mRNA decay by cytoplasmic …

RNA Polymerase II (pol II) is a large multi-subunit complex that is responsible for the
synthesis of all eukaryotic mRNAs. Its correct and timely recruitment to promoter regions is a …

Inactivation of the von Hippel—Lindau (VHL) tumor suppressor gene is linked to the
hereditary VHL disease and sporadic clear cell renal cell carcinomas (CCRCC). VHL …

We have isolated a novel Drosophila (d) gene coding for two distinct proteins via alternative
splicing: a homologue of the yeast adaptor protein ADA2, dADA2a, and a subunit of RNA …

The steady-state level of mRNAs is determined by the balance between their synthesis by
RNA polymerase II (Pol II) and their decay. In the cytoplasm, mRNAs are degraded by two …

In transcriptional regulation, RNA polymerase II (pol II) interacts and forms complexes with a
number of protein factors. To isolate and identify the pol II-associated proteins, we …