Corroles at work: A small macrocycle for great applications

C Di Natale, CP Gros, R Paolesse - Chemical Society Reviews, 2022 - pubs.rsc.org
Corrole chemistry has witnessed an impressive boost in studies in the last 20 years, thanks
to the possibility of preparing corrole derivatives by simple synthetic procedures. The …

[HTML][HTML] Mouse models of colorectal cancer: Past, present and future perspectives

F Bürtin, CS Mullins, M Linnebacher - World journal of …, 2020 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

[HTML][HTML] LOX-1 and cancer: an indissoluble liaison

M Murdocca, C De Masi, S Pucci, R Mango… - Cancer gene …, 2021 - nature.com
Recently, a strong correlation between metabolic disorders, tumor onset, and progression
has been demonstrated, directing new therapeutic strategies on metabolic targets. OLR1 …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease

A Akhmedov, T Sawamura, CH Chen… - European heart …, 2021 - academic.oup.com
Cardiovascular diseases (CVDs), specifically lipid-driven atherosclerotic CVDs, remain the
number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) …

Targeting the tumor microenvironment in colorectal peritoneal metastases

W Ceelen, RG Ramsay, V Narasimhan, AG Heriot… - Trends in cancer, 2020 - cell.com
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC)
patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the …

[HTML][HTML] Involvement of LDL and ox-LDL in cancer development and its therapeutical potential

CF Deng, N Zhu, TJ Zhao, HF Li, J Gu, DF Liao… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorder is related to an increased risk of tumorigenesis and is involved in
the rapid growth of cancer cells as well as the formation of metastatic lesions …

[HTML][HTML] Machine learning phenomics (MLP) combining deep learning with time-lapse-microscopy for monitoring colorectal adenocarcinoma cells gene expression …

M D'Orazio, M Murdocca, A Mencattini, P Casti… - Scientific Reports, 2022 - nature.com
High-throughput phenotyping is becoming increasingly available thanks to analytical and
bioinformatics approaches that enable the use of very high-dimensional data and to the …

[HTML][HTML] The role of C-type lectin receptor signaling in the intestinal microbiota-inflammation-cancer axis

M Li, R Zhang, J Li, J Li - Frontiers in Immunology, 2022 - frontiersin.org
As a subset of pattern recognition receptors (PRRs), C-type lectin-like receptors (CLRs) are
mainly expressed by myeloid cells as both transmembrane and soluble forms. CLRs …

[HTML][HTML] Knockdown of OLR1 weakens glycolytic metabolism to repress colon cancer cell proliferation and chemoresistance by downregulating SULT2B1 via c-MYC

T Zhao, Y Li, K Shen, Q Wang, J Zhang - Cell death & disease, 2021 - nature.com
Chemoresistance is one of the major problems of colon cancer treatment. In tumors,
glycolytic metabolism has been identified to promote cell proliferation and chemoresistance …

The oxidized‐LDL/LOX‐1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells

T Tsumita, N Maishi, DAM Annan… - … journal of cancer, 2022 - Wiley Online Library
Epidemiological relationships between cancer and cardiovascular diseases have been
reported, but a molecular basis remains unclear. Some proteoglycans that strongly bind low …