[HTML][HTML] Adult neurogenesis in the mammalian brain: significant answers and significant questions

G Ming, H Song - Neuron, 2011 - cell.com
Adult neurogenesis, a process of generating functional neurons from adult neural
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

W Deng, JB Aimone, FH Gage - Nature reviews neuroscience, 2010 - nature.com
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an
important role for adult hippocampal neurogenesis in learning and memory, but its specific …

Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor

GZ Wei, KA Martin, PY Xing… - Proceedings of the …, 2021 - National Acad Sciences
While modulatory effects of gut microbes on neurological phenotypes have been reported,
the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan …

Mitochondrial dysfunction in depression

Y Bansal, A Kuhad - Current neuropharmacology, 2016 - ingentaconnect.com
Background: Depression is the most debilitating neuropsychiatric disorder with significant
impact on socio-occupational and well being of individual. The exact pathophysiology of …

[HTML][HTML] N, N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

JA Morales-Garcia, J Calleja-Conde… - Translational …, 2020 - nature.com
Abstract N, N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally
used for ritual and therapeutic purposes across several South American countries. Here, we …

Functions and dysfunctions of adult hippocampal neurogenesis

KM Christian, H Song, G Ming - Annual review of neuroscience, 2014 - annualreviews.org
Adult neurogenesis, a developmental process of generating functionally integrated neurons,
occurs throughout life in the hippocampus of the mammalian brain and showcases the …

Adult hippocampal neurogenesis in depression

A Sahay, R Hen - Nature neuroscience, 2007 - nature.com
The development of new treatments for depression is predicated upon identification of
neural substrates and mechanisms that underlie its etiology and pathophysiology. The …

Emerging roles of Wnts in the adult nervous system

NC Inestrosa, E Arenas - Nature Reviews Neuroscience, 2010 - nature.com
The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

W Cai, T Yang, H Liu, L Han, K Zhang, X Hu… - Progress in …, 2018 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

[HTML][HTML] A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain

S Ge, C Yang, K Hsu, G Ming, H Song - Neuron, 2007 - cell.com
Active adult neurogenesis occurs in discrete brain regions of all mammals and is widely
regarded as a neuronal replacement mechanism. Whether adult-born neurons make unique …