With a growing aged population, there is an imminent need to develop new therapeutic
strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis …

In cancer biology, tumor-promoting inflammation and an inflammatory microenvironment
play a vital role in disease pathogenesis. In the past decade, aberrant innate immune …

Chronic innate immune signaling in hematopoietic cells is widely described in
myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly …

Hematopoietic ageing involves declining erythropoiesis and lymphopoiesis, leading to
frequent anaemia and decreased adaptive immunity. How intrinsic changes to the …

Nicotinamide adenine dinucleotide (NAD+) is indispensable for the anti-aging activity of the
sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD+ …

Myelodysplastic syndromes (MDS) are age-related myeloid neoplasms with increased risk
of progression to acute myeloid leukemia (AML). The mechanisms of transformation of MDS …

Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Myelodysplastic syndromes (MDS) comprise a diverse group of clonal and malignant
myeloid disorders characterized by ineffective hematopoiesis, resultant peripheral …

Myelodysplastic syndrome (MDS) is characterized by bone marrow failure and a strong
propensity for leukemic evolution. Somatic mutations are critical early drivers of the disorder …

Aging is associated with significant changes in the hematopoietic system, including
increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased …