With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased
in Lewy body disease, such as Parkinson's disease (PD) and dementia with Lewy bodies …

The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease
(PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through
the nervous system in a variety of neurodegenerative disorders including Parkinson's …

Alzheimer disease (AD) is the leading cause of dementia that affects millions of old people.
Despite significant advances in the understanding of AD pathobiology, no disease modifying …

Pain is a common non-motor symptom of Parkinson's disease (PD), with current limited
knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha …

Abstract Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble
fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a …