In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop.
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …

As the building blocks of chromatin, histones are central to establish and maintain particular
chromatin states associated with given cell fates. Importantly, histones exist as distinct …

Chromatin accessibility is a hallmark of active regulatory regions and is functionally linked to
transcriptional networks and cell identity. However, the molecular mechanisms and networks …

Transcription factor (TF) databases contain multitudes of binding motifs (TFBMs) from
various sources, from which non-redundant collections are derived by manual curation. The …

E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4
often represents the predominant E2F activity in cells. E2F4 is a transcriptional repressor …

Anti–Müllerian hormone (AMH) produced by ovarian granulosa cells (GCs) plays a crucial
role in ovarian function. It is used as a diagnostic and/or prognostic marker of fertility as well …

Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girls with
heterozygous mutations in the gene encoding the methyl-CpG–binding protein MeCP2 on …

Histone H1 is a structural component of chromatin that may have a role in the regulation of
chromatin dynamics. Unlike core histones, the linker histone H1 family is evolutionarily …

Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …

Background Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate
into every cell type and to self-renew. These characteristics correlate with a distinct nuclear …