In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Scanning ion conductance microscopy (SICM) has emerged as a versatile tool for studies of
interfaces in biology and materials science with notable utility in biophysical and …

Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic
output in contractile cells. Several studies have demonstrated that calcium (Ca 2+) plays a …

Rationale: 3′, 5′-cAMP is a ubiquitous second messenger which, upon β-AR (β-
adrenergic receptor) stimulation, acts in microdomains to regulate cardiac excitation …

Aim In cardiomyocytes, transverse tubules (T-tubules) associate with the sarcoplasmic
reticulum (SR), forming junctional membrane complexes (JMCs) where L-type calcium …

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …

Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000
deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Rationale: Mutations in the LMNA gene, encoding nuclear inner membrane protein lamin
A/C, cause distinct phenotypes, collectively referred to as laminopathies. Heart failure …