The last two decades have shown impressive advances in high-throughput assays for gene
expression (genomics), proteins (proteomics), and metabolites (metabolomics). As a result …

Objectives Dexamethasone has now been incorporated into the standard of care for COVID-
19 hospital patients. However, larger intensive care unit studies have failed to show …

Biorepositories provide a critical resource for gaining knowledge of emerging infectious
diseases and offer a mechanism to rapidly respond to outbreaks; the emergence of the …

Abstract Background Coronavirus disease 2019 (COVID-19) is a viral pneumonia that can
result in serious respiratory illness. It is associated with extensive systemic inflammation …

Background Post-coma patients emerging from a minimally conscious state may have
extensive motor disabilities and pose serious challenges to medical centers and home …

Background and aims Although obesity have been generally shown to be an independent
risk factor for poor outcomes in COVID-19 infection, some studies demonstrate a paradoxical …

Abstract Interleukin (IL)-33 is released following tissue damage, causing airway
inflammation and remodelling via reduced IL-33 (IL-33 red)/serum stimulation-2 (ST2) and …

Background Chronic obstructive pulmonary disease (COPD) patients are at increased risk of
poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe …

The COVID-19 pandemic led to a broad implementation of proning to enhance oxygenation
in both self-ventilating and mechanically ventilated critically ill patients with acute severe …

We present a framework for a federated, virtual biorepository system (VBS) with locally
collected and managed specimens, as a 'global public good'model based on principles of …