The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Calcineurin is a calcium activated protein phosphatase with a major role in calcium
signaling in diverse cells and organs and clinical importance as the target of the …

Regulatory enzymes often have different roles in distinct subcellular compartments. Yet,
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …

N-methyl-d-aspartate (NMDA) receptors are the major mediator of excitotoxicity. Although
physiological activation of the NMDA receptor is necessary for cell survival, overactivation is …

Neuronal L-type calcium channels contribute to dendritic excitability and activity-dependent
changes in gene expression that influence synaptic strength. Phosphorylation-mediated …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …

Plasticity at excitatory glutamatergic synapses in the central nervous system is believed to
be critical for neuronal circuits to process and encode information, allowing animals to …

The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …

Abstract A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …

African swine fever virus (ASFV) can cause an acutely fatal haemorrhagic fever in domestic
pigs although in its natural hosts, warthogs, bushpigs and the soft tick vector, Ornithodoros …