Current status of N-, O-, S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview
Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
RH Sharafat, A Saeed - Purinergic Signalling, 2024 - Springer
Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively
targeting ectonucleotidases, are essential in altering purinergic signaling pathways. The …
targeting ectonucleotidases, are essential in altering purinergic signaling pathways. The …
Synthesis and discovery of potential tyrosinase inhibitor of new coumarin‐based thiophenyl‐pyrazolylthiazole nuclei: In vitro evaluation, cytotoxicity, kinetic, and …
N Hosseini Nasab, H Raza, YS Eom… - Chemical Biology & …, 2023 - Wiley Online Library
A well‐known key enzyme in melanogenesis and hyperpigmentation is tyrosinase. The
present study introduces a novel series of thiophenyl‐pyrazolylthiazole‐coumarin hybrids …
present study introduces a novel series of thiophenyl‐pyrazolylthiazole‐coumarin hybrids …
A facile green synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones using cysteine as a bio-organic catalyst: Potent urease inhibitors, in vitro evaluation, kinetic mechanism …
The aim of the present research was to develop a one-pot, three-component method for the
synthesis of some 3, 4-dihydro pyrimidine-2-(1H)-one (DHPM) derivatives using aldehydes …
synthesis of some 3, 4-dihydro pyrimidine-2-(1H)-one (DHPM) derivatives using aldehydes …
Design and synthesis of thiadiazole-oxadiazole-acetamide derivatives: Elastase inhibition, cytotoxicity, kinetic mechanism, and computational studies
Considering the biological significance of 1, 3, 4-thiadiazole/oxadiazole heterocyclic
scaffolds, a novel series of 1, 3, 4-thiadiazole-1, 3, 4-oxadiazole-acetamide derivatives (7a …
scaffolds, a novel series of 1, 3, 4-thiadiazole-1, 3, 4-oxadiazole-acetamide derivatives (7a …
DNA-methylation signatures of tobacco smoking in a high cardiovascular risk population: modulation by the Mediterranean diet
R Fernández-Carrión, JV Sorlí, EM Asensio… - International Journal of …, 2023 - mdpi.com
Biomarkers based on DNA methylation are relevant in the field of environmental health for
precision health. Although tobacco smoking is one of the factors with a strong and consistent …
precision health. Although tobacco smoking is one of the factors with a strong and consistent …
Design, synthesis, and in vitro and in silico studies of 1, 3, 4-thiadiazole-thiazolidinone hybrids as carbonic anhydrase inhibitors
In this study, a series of 1, 3, 4-thiadiazole-thiazolidinone derivatives (7a–j) were
synthesized as carbonic anhydrase inhibitors. The in vitro carbonic anhydrase inhibitory …
synthesized as carbonic anhydrase inhibitors. The in vitro carbonic anhydrase inhibitory …
Putting forward novel sulfonamide-thiazole-pyrazoline hybrids as potential central core structure for the development of non-specific b-TNAP and c-IAP inhibitors
MB Haider, A Saeed, M Azeem, SA Ullah… - International Journal of …, 2024 - Elsevier
Alkaline phosphatases (ALPs) play crucial role in various functions of human body, such as
bone formation, metabolism in liver and intestines, and transfer of nutrients from mother to …
bone formation, metabolism in liver and intestines, and transfer of nutrients from mother to …
[HTML][HTML] In Silico Prediction of Alkaline Phosphatase Interaction with the Natural Inhibitory 5-Azaindoles Guitarrin C and D
A Seitkalieva, Y Noskova, M Isaeva, A Guzii… - Molecules, 2024 - mdpi.com
The natural 5-azaindoles, marine sponge guitarrin C and D, were observed to exert
inhibitory activity against a highly active alkaline phosphatase (ALP) CmAP of the PhoA …
inhibitory activity against a highly active alkaline phosphatase (ALP) CmAP of the PhoA …
Heteroleptic Zn (II) Complexes; Synthesis, Spectral Characterization, DNA Interaction, Enzyme Inhibition and Docking Studies
S Muzaffar, S Naz, F Mazhar, Z Rashid, M Bibi… - Journal of Molecular …, 2024 - Elsevier
Herein, the synthesis of four heteroleptic zinc (II) carboxylates (MPAa1-MPAa4) was carried
out using 2-methoxyphenylacetic acid (as a primary ligand) and nitrogen donor heterocycles …
out using 2-methoxyphenylacetic acid (as a primary ligand) and nitrogen donor heterocycles …