The therapeutic potential of carnosine/anserine supplementation against cognitive decline: A systematic review with meta-analysis

G Caruso, J Godos, S Castellano, A Micek, P Murabito… - Biomedicines, 2021 - mdpi.com
Carnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging
agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at …

The therapeutic potential of carnosine as an antidote against drug-induced cardiotoxicity and neurotoxicity: Focus on nrf2 pathway

G Caruso, A Privitera, BM Antunes, G Lazzarino… - Molecules, 2022 - mdpi.com
Different drug classes such as antineoplastic drugs (anthracyclines, cyclophosphamide, 5-
fluorouracil, taxanes, tyrosine kinase inhibitors), antiretroviral drugs, antipsychotic, and …

Unveiling the hidden therapeutic potential of carnosine, a molecule with a multimodal mechanism of action: A position paper

G Caruso - Molecules, 2022 - mdpi.com
Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous dipeptide and an over-
the-counter food supplement with a well-demonstrated multimodal mechanism of action that …

Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis

F Hadi, S Kashefinejad, L Kamalzadeh… - BMC Pharmacology and …, 2021 - Springer
Background Obsessive-compulsive disorder (OCD) is among the most disabling
neuropsychiatric conditions characterized by the presence of repetitive intrusive thoughts …

The contribution of polyamine pathway to determinations of diagnosis for treatment-resistant depression: A metabolomic analysis

Z You, C Wang, X Lan, W Li, D Shang, F Zhang… - Progress in Neuro …, 2024 - Elsevier
Objectives Approximately one-third of major depressive disorder (MDD) patients do not
respond to standard antidepressants and develop treatment-resistant depression (TRD). We …

Cognitive rehabilitation for improving cognitive functions and reducing the severity of depressive symptoms in adult patients with major depressive disorder: a …

S Mokhtari, A Mokhtari, F Bakizadeh, A Moradi… - BMC psychiatry, 2023 - Springer
Introduction Nearly 40% of patients with Major Depressive Disorder (MDD) have been found
to experience cognitive impairment in at least one domain. Cognitive impairment associated …

The therapeutic potential of novel carnosine formulations: perspectives for drug development

A Bonaccorso, A Privitera, M Grasso, S Salamone… - Pharmaceuticals, 2023 - mdpi.com
Carnosine (beta-alanyl-L-histidine) is an endogenous dipeptide synthesized via the activity
of the ATP-dependent enzyme carnosine synthetase 1 and can be found at a very high …

Microfluidic/HPLC combination to study carnosine protective activity on challenged human microglia: Focus on oxidative stress and energy metabolism

A Privitera, V Cardaci, D Weerasekara… - Frontiers in …, 2023 - frontiersin.org
Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely
distributed in excitable tissues such as the brain. This dipeptide possesses well …

Safety and side effects of psychotropic medications

R de Filippis, M Solerdelcoll, M Shalbafan - Frontiers in Psychiatry, 2023 - frontiersin.org
In the last few decades psychopharmacology has witnessed an incredible development in
terms of efficacy, safety and number of options available for the treatment and management …

Carnosine as a possible drug for zinc-induced neurotoxicity and vascular dementia

M Kawahara, Y Sadakane, K Mizuno… - International Journal of …, 2020 - mdpi.com
Increasing evidence suggests that the metal homeostasis is involved in the pathogenesis of
various neurodegenerative diseases including senile type of dementia such as Alzheimer's …