Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since
ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9 …

Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a
wide range of therapeutically promising pharmacological effects either as a sole drug or in …

Background The use of cannabis, or marijuana, for medicinal purposes is deeply rooted
though history, dating back to ancient times. It once held a prominent position in the history …

A multitude of roles for the endogenous cannabinoid system has been proposed by recent
research efforts. A large number of endogenous cannabinoid neurotransmitters or …

Cannabinoids can modulate motor behaviour, learning and memory, cognition and pain
perception. These effects correlate with the expression of the cannabinoid receptor 1 (CB1) …

The active compound in herbal cannabis, Δ9‐tetrahydrocannabinol, exerts all of its known
central effects through the CB1 cannabinoid receptor. Research on cannabinoid …

The tongue is a complex multifunctional organ that interacts and senses both interoceptively
and exteroceptively. Although it is easily visible to almost all of us, it is relatively …

Rationale: Central cannabinoid systems have been implicated in appetite regulation by the
respective hyperphagic actions of exogenous cannabinoids, such as Δ9-THC, and …

SR 141716, a selective central CB1 cannabinoid receptor antagonist, markedly and
selectively reduces sucrose feeding and drinking as well as neuropeptide Y-induced …