The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is a feature of specialized secretory cells and is also observed in many diseases, including …

Excessive cellular oxidative stress is widely perceived as a key factor in pathophysiological
conditions and cancer development. Healthy cells use several mechanisms to maintain …

The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular
functions including protein folding and maturation and the maintenance of cellular …

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is observed in many human diseases, including cancers. Cellular adaptation to ER stress is …

The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate
has not markedly improved, despite new radical surgery protocols, the introduction of new …

OBJECT Chloroquine (CQ) is a quinoline-based drug widely used for the prevention and
treatment of malaria. More recent studies have provided evidence that this drug may also …

The endoplasmic reticulum (ER) is responsible for many housekeeping functions within the
cell and is an important site for pathways that regulates its state of homeostasis. When …

Object In a recent clinical trial, patients with newly diagnosed glioblastoma multiforme
benefited from chloroquine (CQ) in combination with conventional therapy (resection …