The human JC polyomavirus (JCPyV): virological background and clinical implications
HH Hirsch, P Kardas, D Kranz, C Leboeuf - Apmis, 2013 - Wiley Online Library
JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …
PyV particles were revealed by electron microscopy in progressive multifocal …
Persistence and pathogenesis of the neurotropic polyomavirus JC
HS Wollebo, MK White, J Gordon, JR Berger… - Annals of …, 2015 - Wiley Online Library
Many neurological diseases of the central nervous system (CNS) are underpinned by
malfunctions of the immune system, including disorders involving opportunistic infections …
malfunctions of the immune system, including disorders involving opportunistic infections …
The biology of JC polyomavirus
B Assetta, WJ Atwood - Biological chemistry, 2017 - degruyter.com
JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system
demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML …
demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML …
New insights on human polyomavirus JC and pathogenesis of progressive multifocal leukoencephalopathy
A Bellizzi, E Anzivino, DM Rodio… - Journal of …, 2013 - Wiley Online Library
John Cunningham virus (JCV) is a member of the Polyomaviridae family. It was first isolated
from the brain of a patient with Hodgkin disease in 1971, and since then the etiological …
from the brain of a patient with Hodgkin disease in 1971, and since then the etiological …
Understanding progressive multifocal leukoencephalopathy risk in multiple sclerosis patients treated with immunomodulatory therapies: a bird's eye view
EA Mills, Y Mao-Draayer - Frontiers in Immunology, 2018 - frontiersin.org
The increased use of newer potent immunomodulatory therapies for multiple sclerosis (MS),
including natalizumab, fingolimod, and dimethyl fumarate, has expanded the patient …
including natalizumab, fingolimod, and dimethyl fumarate, has expanded the patient …
Sp1 sites in the noncoding control region of BK polyomavirus are key regulators of bidirectional viral early and late gene expression
T Bethge, HA Hachemi, J Manzetti, R Gosert… - Journal of …, 2015 - Am Soc Microbiol
In kidney transplant patients with BK polyomavirus (BKPyV) nephropathy, viral variants arise
bearing rearranged noncoding control regions (rr-NCCRs) that increase viral early gene …
bearing rearranged noncoding control regions (rr-NCCRs) that increase viral early gene …
JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the …
T Van Loy, K Thys, C Ryschkewitsch, O Lagatie… - Journal of …, 2015 - Am Soc Microbiol
Opportunistic infection of oligodendrocytes by human JC polyomavirus may result in the
development of progressive multifocal encephalopathy in immunocompromised individuals …
development of progressive multifocal encephalopathy in immunocompromised individuals …
B cells and progressive multifocal leukoencephalopathy: search for the missing link
D Durali, MG de Goër de Herve, J Gasnault… - Frontiers in …, 2015 - frontiersin.org
Progressive multifocal leukoencephalopathy (PML) is a deadly demyelinating disease due
to JC virus (JCV) replication in the brain. PML classically occurs in patients with severe …
to JC virus (JCV) replication in the brain. PML classically occurs in patients with severe …
ViroFind: A novel target-enrichment deep-sequencing platform reveals a complex JC virus population in the brain of PML patients
S Chalkias, JM Gorham, E Mazaika, M Parfenov… - PLoS …, 2018 - journals.plos.org
Deep nucleotide sequencing enables the unbiased, broad-spectrum detection of viruses in
clinical samples without requiring an a priori hypothesis for the source of infection. However …
clinical samples without requiring an a priori hypothesis for the source of infection. However …
Immune system involvement in the pathogenesis of JC virus induced PML: what is learned from studies of patients with underlying diseases and therapies as risk …
MCG Monaco, EO Major - Frontiers in immunology, 2015 - frontiersin.org
The human polyomavirus JC PyV lytic infection of oligodendrocytes in the human brain
results in the demyelinating disease progressive multifocal leukoencephalopathy, PML. JCV …
results in the demyelinating disease progressive multifocal leukoencephalopathy, PML. JCV …