Next-generation sequencing technology has rapidly accelerated the discovery of genetic
variants of interest in individuals with rare diseases. However, showing that these variants …

Cicer arietinum L. is the third greatest widely planted imperative pulse crop worldwide, and it
belongs to the Leguminosae family. Drought is the utmost common abiotic factor on plants …

We generated a library of~ 1000 Drosophila stocks in which we inserted a construct in the
intron of genes allowing expression of GAL4 under control of endogenous promoters while …

The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

We previously reported a CRISPR-mediated knock-in strategy into introns of Drosophila
genes, generating an attP-FRT-SA-T2A-GAL4-polyA-3XP3-EGFP-FRT-attP transgenic …

Decreased sequencing costs have led to an explosion of genetic and genomic data. These
data have revealed thousands of candidate human disease variants. Establishing which …

The fruit fly, Drosophila melanogaster, has been used to understand fundamental principles
of genetics and biology for over a century. Drosophila is now also considered an essential …

The development of fluorescent labels and powerful imaging technologies in the last two
decades has revolutionized the field of fluorescence microscopy, which is now widely used …

Next-generation sequencing has greatly accelerated the discovery of rare human genetic
diseases. Nearly 45% of patients have variants associated with known diseases but the …

Development of effective therapies against SARS-CoV-2 infections relies on mechanistic
knowledge of virus-host interface. Abundant physical interactions between viral and host …