At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

Niemann–Pick type C disease (NPCD) was first described in 1914 and affects approximately
1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver …

Atherosclerosis is a leading cause of cardiovascular disease worldwide, and
hypercholesterolemia is a major risk factor. Preventive treatments mainly focus on the …

Adenosine is an endogenous nucleoside with a short half-life that regulates many
physiological functions involving the heart and cardiovascular system. Among the …

Inflammation is paradoxical; it is essential for protection following biological, chemical or
physical stimuli, but inappropriate or misdirected inflammation is responsible for tissue injury …

The effect and clinical benefit of P2Y12 receptor antagonists may not be limited to platelet
inhibition and the prevention of arterial thrombus formation. Potential additional effects …

Resveratrol is a bioactive molecule used in dietary supplements and herbal medicines and
consumed worldwide. Known cardioprotective and anti-inflammatory properties of …

The production of adenosine represents a critical endogenous mechanism for regulating
immune and inflammatory responses during conditions of stress, injury, or infection …