Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

Despite more than a century of research, the aetiology of sporadic Alzheimer's disease (AD)
remains unclear and finding disease modifying treatments for AD presents one of the …

We present a technique for automatically assigning a neuroanatomical label to each voxel in
an MRI volume based on probabilistic information automatically estimated from a manually …

Background Alzheimer's disease (AD) pathology is common in patients with amnestic mild
cognitive impairment (aMCI) without dementia, but the prevalence of AD pathology in …

Why are some people more mentally able than others? In an authoritative, critical and
intergrated series of review essays Professor Ian Deary inquires after the cognitive and …

The ε4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's
disease and may also affect cognitive performance in normal aging. Evidence of the …

Although atrophic changes have been well described following traumatic brain injury (TBI) in
humans, little is known concerning the mechanisms or progression of brain tissue loss. In …

Background: Mild cognitive impairment (MCI) has attracted considerable interest as a
potential predictor of Alzheimer's disease (AD). Both the apolipoprotein E (ApoE) Ε4 allele …

Accuracy of clinical diagnosis of dementia is increasingly important for therapeutic and
scientific investigations. In this study, we examine diagnostic accuracy in a consecutive …

The ε4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for
Alzheimer's disease (AD), but limited work has suggested that APOE genotype may …