Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

Trillions of microbes are indigenous to the human gastrointestinal tract, together forming an
ecological community known as the gut microbiota. The gut microbiota is involved in dietary …

Background The microbiota inhabits the epithelial surfaces of hosts, which influences
physiological functions from helping digest food and acquiring nutrition to regulate …

Intestinal microbiota and their metabolites are essential for maintaining intestinal health,
regulating inflammatory responses, and enhancing the body's immune function. An …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by
late diagnosis, rapid progression, and a high mortality rate. Its complex biology …

Background Cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) pathway, which is
regulated by aryl hydrocarbon receptor (AhR) plays an important role in chemical …

Platinum-based drugs (PBDs), including cisplatin, carboplatin, and oxaliplatin, have been
widely used in clinical practice as mainstay treatments for various types of cancer. Although …

In recent years, the incidences and mortalities from colorectal cancer (CRC) have been
increasing; therefore, there is an urgent need to discover newer drugs that enhance drug …